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Marti Roger

Marti Roger

Ordentlicher Professor FH


MAIN SKILLS

Organic Chemistry

Green & Sustainable Chemistry

Process Chemistry

Flow Chemistry

Polymers

Asymmetric Synthesis

Catalysis


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Contrat principal

Ordentlicher Professor FH

Phone: +41 26 429 67 03

Desktop: B20.05

Haute école d'ingénierie et d'architecture de Fribourg
Boulevard de Pérolles 80, 1700 Fribourg, CH
Haute école d'ingénierie et d'architecture de Fribourg

Institute
ChemTech - Institut des technologies chimiques

HES-SO Master
Av. de Provence 6, 1007 Lausanne, CH
HES-SO Master

Faculty
Chimie et sciences de la vie
Main Degree Programme
Master of Science in Life sciences

Teaching of organic chemistry and related topics on Bachelor and Master Level

Competences in synthetic organic chemistry and process chemistry, chiral catalysis, new synthesis technologies like flow chemistry, and molecules for applications in life sciences

BA HES-SO en Architecture - Haute école d'ingénierie et d'architecture de Fribourg

  • Chimie organique 4 - Composés aromatiques & dérivés carbonylés

BSc HES-SO en Chimie - Haute école d'ingénierie et d'architecture de Fribourg

  • Chimie organique 5 - Dérivés d’acides carboxyliques & amines

Ongoing

NCCR ' Single Atom Catalysis PRD

Role: Main Applicant

Description du projet : NCCR Catalysis - Ph.D. Project 'Single Atom Catalysis - Industrial Application"

Research team within HES-SO: Bourrier Hervé, Marti Roger, Poier Dario

Partenaires académiques: FR - EIA - Institut ChemTech

Durée du projet: 12.10.2020 - 31.08.2024

Statut: Ongoing


Ionic Liquid PCM for smart building applications

Role: Co-applicant

Description du projet : Smart buildings and the energy strategy 2050 are at the origin of an important demand for compact and demand-oriented thermal storage. One solution to meet these requirements is the use of new PCMs with on-demand activation and intelligent control of the heat&cold storage, charge and discharge processes. This means that new PCM must be developed together with a measurement system of their capacity and storage level. In this project, we prepare novel sustainable phase change materials (PCM) based on ionic liquids (IL) from natural & renewable sources. These IL-PCMs are tested to the stage of an initial demonstrator and are designed to store & manage heat in smart buildings.

Research team within HES-SO: Marti Roger

Durée du projet: 03.06.2019 - 31.12.2020

Statut: Ongoing


Des biocarburants à base de PHA pour une mobilité durable et neutre en CO2

Role: Main Applicant

Description du projet : Statistic figures for mobility and traffic in 2018 show that cars and leisure activities prevails in passenger transportation. The car is the most common transport means with an average of 10'370 km per year. Each Swiss citizen consumes on average 700 L of fossil fuels yearly and transport accounts for 39% of CO2 emissions of Switzerland. To reduce these emissions, sustainable biofuels are required. Fossil fuels are already blended with biodiesel or bioethanol from renewable resources, but this corresponds to only 3% of total fuel consumption. Furthermore, biofuels production is currently in competition with food sources. Although electro-mobility is emerging, there are still more than 6 million petrol/diesel vehicles in operation inSwitzerland - there is an evolution, but not a revolution in the vehicle population. To this end, solutions for sustainable fuels needs to be developed rapidly, which a) can be integrated into the existing infrastructure, b) are CO2-neutral and c) do not compete with food supply. This is where our project comes in: many bacteria naturally accumulate polyhydroxyalkanoate (PHA) in presence of carbon substrate when another nutrient (nitrogen or phosphorus) is limiting growth. The first goal of this project is to establish a bioprocess with microorganisms that are able to produce PHA from CO2. The second goal of this project is to chemically convert PHA further to biofuels. There are first reports about PHA based biofuels, but the oxygen content of these compounds is very high ' up to 40%, which allows a blending of only a few % in diesel. Our approach goes further, as, through depolymerization and hydrogenation (from H2 from solar water splitting), we can produce high quality biofuels not competing with food & feed sources. Considering a larger implementation of the process, we assess the ecologic potential of our new PHA-based biofuel and compare it to alternative and existing competing technologies on a life cycle assessment (LCA) basis. This approach also feedbacks to the biofuel production process, providing bounding conditions and requirements regarding both its potential production costs and environmental impacts. To summarize: ' There is an urgent need for novel, sustainable biofuels ' our approach is innovative and we have the competencies in PHA production, chemistry and catalysis for biofuel production and characterization. ' Preliminary LCA to estimate ecological impact as well as the potential of PHA-based biofuels. ' Scale-up of one of the bioprocess for PHA production and of chemical biofuel synthesis to > 1 kg scale for proof-of-concept. ' Test of the new PHA-based biofuels in an engine test bench unveiling the potential of this novel and innovative biofuel production chain. ' Valorization of the project through dissemination of the results and research of third-party funding, especially for a further integration of industrial glycerol wastes and CO2 exhaust gas as feedstocks.

Research team within HES-SO: Pott Julien, Micaux Fabrice, Zinn Manfred, Pilloud Vincent, Dardano Florian, Miserez Florian, Albergati Luce, Nellen Christian, Alber Bastien, Maruel Frédéric, Sthioul Hervé, Richard Jacques, Hanik Nils, Utsunomia Camila, Amstutz Véronique, Marti Roger

Partenaires académiques: HES-SO Rectorat; VS - Institut Technologies du vivant; hepia inSTI; FR - EIA - Institut ChemTech; Marti Roger, FR - EIA - Institut ChemTech

Durée du projet: 19.02.2019 - 30.09.2021

Statut: Ongoing


Bio-based smart packaging for enhanced preservation of food quality

Role: Co-applicant

Financement: FR - EIA - Institut iRAP; Horizon 2020; FR - EIA - Institut iRAP

Description du projet : The BIOSMART project proposal has the ambition to develop active and smart bio-based and compostable packages addressing the needs of several food market segments. The knowledge gained from developing the novel packages forms the basis for tailoring performance and functionality to other flexible and rigid food packages in diverse market segments. An holistic ecosystem approach is pursued by offering solutions that bring enhanced performance and acceptable economics to the packaging value chain to facilitate their implementation and large-scale commercialization. Critical issues that differentiate the present packages from the future all-bio-based and compostable ones are enhanced active and smart functionalities that make possible: light weighting, reduced food residues, shelf life monitoring and longer shelf life, easier consumer waste handling, and all this at a competitive cost to the incumbent. The BIOSMART project proposal develops an approach for selectively integrating superhydrophobic surfaces, microencapsulated phase change materials (thermoregulation), barrier coatings, very low cost sensor devices, and new bio-based and active ingredients (anti-microbial, anti-fungal, and antioxidants), into all-bio-based compostable packages. Three generic packaging systems are selected with specific performance needs as defined by current multi-material fossil-fuel based packages (i.e. pouches, terrines and an hybrid carton/thin film tray). The associate life cycle assessments for the different possible scenarios include the economic feasibility as a defining key performance indicator. Ultimately, the gathered developmental knowledge is consolidated in a material selection and package performance simulation Application. It enables through optimization of key performance indicators and representing emulators a quick selection of relevant plastics, packaging composition, and cost.

Research team within HES-SO: Brodard Pierre, Hennebert Jean, Blanchard Lucien, Albergati Luce, Esseiva Julien, Zurbuchen Nicolas, Koopmans Rudolf, Mavrozoumi Vasiliki, Rychener Lorenz, Marti Roger

Partenaires académiques: FR - EIA - Institut ChemTech; FR - EIA - Institut iCoSys

Durée du projet: 21.12.2016 - 30.09.2021

Statut: Ongoing


Completed

Call 2011 Production d'énergie propre en milieu urbain basé sur la transformation du CO2 en méthanol offrant un biocarburant neutre en CO2 utilisé dans le cadre de la mobilité urbaine et d'une autonomisation énergétique des bâtiments.

Role: Collaborator

Requérant(e)s: FR - EIA - Institut ChemTech

Financement: HES-SO Rectorat

Description du projet : La transformation du CO2 en méthanol représente une énergie propre renouvelable et facile à stocker, permettant à la Suisse de relever les défis environnementaux et économiques en lien avec la problématique de l'énergie. La solution proposée offre une production de carburant neutre en CO2 pour des applications en milieu urbain (voitures et pompes à chaleur utilisant une pile au méthanol) se basant sur une vision de bâtiments et de familles autonomes du point de vue énergique.

Research team within HES-SO: Dabros Michal, Grèzes Vincent, Favre-Perrod Patrick, Sanglard Pauline, Perruchoud Antoine, Bourrier Hervé, Vorlet Olivier, Naef Olivier, Richard Jacques, Chappuis Thierry, Marti Roger, Amrein Daniel, Mamula Steiner Olimpia, Bourgeois Jean-Pascal, Ropp Julien

Partenaires académiques: IGT; VS - Institut Entrepreneuriat & MANAGEMENT; hepia inSTI; FR - EIA - Institut ChemTech; FR - EIA - Institut ENERGY

Durée du projet: 20.03.2012 - 09.06.2015

Statut: Completed


Calibrage d'une méthode de comptage des sangliers par capture-marquage-recapture.

Role: Co-applicant

Description du projet : Le sanglier est étroitement lié aux activités humaines en tant qu'espèce gibier appréciée des chasseurs, mais également de par les dégâts agricoles. Ces derniers sont en forte progression et les besoins de gérer cette espèce sont de plus en plus marqués. Le problème pour réaliser une gestion mesurée réside dans la grande difficulté d'évaluer la taille et la distribution des populations, des données indispensables pour pouvoir établir les plans de gestion. Nous proposons une méthode nouvelle d'évaluation des effectifs. Cette méthode doit être calibrée, de façon à évaluer son adéquation. Le but final est de proposer aux gestionnaires, en Suisse et à l'étranger, une méthode précise et facilement applicable. Le projet devrait débuter en juin 2012 et durer 2 années. Il permettra à l'InTNE d'augmenter sa présence et sa reconnaissance au niveau de la gestion des ongulés auprès des administrations cantonales et fédérales, des spécialistes de la faune et du grand public. Les moyens nécessaires sont principalement des ressources humaines et environ 15 % du budget servira à l'achat de matériel.

Research team within HES-SO: Marti Roger

Durée du projet: 24.01.2013 - 08.10.2014

Statut: Completed




2020

The vitamin C analogue 2-O-ß-D-Glucopyranosyl-L-ascorbic acid in rhizomes, stems and leaves of lycium barbarum ArODES Scientifique

Bubloz Carole, Udrisard Isabelle, Micaux Fabrice, Piantini Umberto, Amini-Rentsch Lara, Marti Roger, Andlauer Wilfried

CHIMIA International Journal for Chemistry, 2020, vol. 74, no. 10, pp. 828-830

Link to the publication

Summary:

Awareness of health benefits of goji berries coming from their bioactive compounds, mostly antioxidants like ascorbic acid, has grown. Recently, an ascorbic acid analogue from goji berries, the 2-O-β-D-glucopyranosyl-L-ascorbic acid has been reported. In rats, the analogue is absorbed intact and in the form of free vitamin C and consequently has been proposed as a provitamin C. Synthesis of the analogue is demanding and laborious and therefore reliable natural sources are searched. Knowledge concerning the analogue's occurrence in other parts of goji plant is lacking. The aim of this study was to evaluate the contents of 2-O-β-D-glucopyranosyl-L-ascorbic acid in rhizomes, stems and leaves from Lycium barbarum. Rhizomes, stems and leaveswere extracted and the content of 2-O-β-D-glucopyranosyl-L-ascorbic acid and non glucosylated, free ascorbic acid was determined by HPLC-DAD. 2-O-β-D-glucopyranosyl-L-ascorbic acid was found in all goji plant tissues investigated. Based on dry weight, 3.34 mg/100 g were found in the leaves, 4.05 mg/100 g in the stems and up to 12.6 mg/100 g in the rhizomes. Nevertheless, the analogue content in goji berries is much higher (40 to 280 mg/100 g dry weight). The present study confirmed the presence of 2-O-β-D-glucopyranosyl-L-ascorbic acid in rhizomes, stems and leaves of Lycium barbarum. However, their content compared to goji berries is considerably lower.




2019

Materials science at Swiss Universities of Applied Sciences ArODES Scientifique

Brodard Pierre, Dabros Michal, Marti Roger, Vanoli Ennio, Zinn Manfred, Frey Urban, Adlhart Christian, Kind Lucy, Koch Franziska, Burgio Floriana, Stenqvist Johan, Saxer Sina, Pieles Uwe, Shahgaldian Patrick, Wendeborn Sebastian

Chimia, 2019, vol. 73, no. 7/8, pp. 645-655

Link to the publication

Summary:

In the Swiss Universities of Applied Sciences, several research institutes are involved in Materials Science, with different approaches and applications fields. A few examples of recent projects from different groups of the University of Applied Sciences and Arts Western Switzerland (HESSO), the Zurich University of Applied Sciences (ZHAW) and the University of Applied Sciences and Arts Northwestern Switzerland (FHNW) are given.


A novel and efficient continuous-flow route to prepare trifluoromethylated N-fused heterocycles for drug discovery and pharmaceutical manufacturing ArODES Scientifique

Amini-Rentsch Lara, Vanoli Ennio, Richard-Bildstein Sylvia, Marti Roger, Vilé Gianvito

Industrial & Engineering Chemistry Research (I & EC research), 2019, vol. 58, no. 24, pp. 10164-10171

Link to the publication

Summary:

Continuous-flow processing has become one of the fastest-growing research areas in chemistry in the last 10 years. Herein we disclose an automated and scalable continuous-flow route for the quick introduction of trifluoromethyl groups on a variety of heterocycles, with application in drug discovery and manufacturing. This involves the direct alkylation-cyclization of amines in the presence of trifluoroacetic acid or anhydride, cheap and readily available CF3-containing building blocks. Compared to traditional batch reactions involving an intermediate purification step, the continuous-flow reactions occurred quickly and at mild conditions, with high yield and broad functional-group tolerance. The practical utility of the method was demonstrated by a gram-scale synthesis and by the estimation of modern green metrics.




2018

4-epi-Isofagomine derivatives as pharmacological chaperones for the treatment of lysosomal diseases linked to ß-galactosidase mutations : improved synthesis and biological investigations ArODES Scientifique

Front Sophie, Almeida Sofia, Zoete Vincent, Charollais-Thoenig Julie, Gallienne Estelle, Marmy Céline, Pilloud Vincent, Marti Roger, Wood Tim, Martin Olivier R., Demotz Stéphane

Bioorganic & Medicinal Chemistry, 2018, vol. 26, no. 20, pp. 5462-5469

Link to the publication

Summary:

(5aR)-5a-C-pentyl-4-epi-isofagomine 1 is a powerful inhibitor of lysosomal β-galactosidase and a remarkable chaperone for mutations associated with GM1-gangliosidosis and Morquio disease type B. We report herein an improved synthesis of this compound and analogs (5a-C-methyl, pentyl, nonyl and phenylethyl derivatives), and a crystal structure of a synthetic intermediate that confirms its configuration resulting from the addition of a Grignard reagent. These compounds were evaluated as glycosidase inhibitors and their potential as chaperones for mutant lysosomal galactosidases determined. Based on these results and on docking studies, the 5-C-pentyl derivative 1 was selected as the optimal structure for further investigations: this compound induces the maturation of mutated β-galactosidase in fibroblasts of a GM1-gangliosidosis patient and promote the decrease of keratan sulfate and oligosaccharide load in patient cells. Compound 1 is clearly capable of restoring β-galactosidase activity and of promoting maturation of the protein, which should result in significant clinical benefit. These properties strongly support the development of compound 1 for the treatment of GM1-gangliosidosis and Morquio disease type B patients harboring β-galactosidase mutations sensitive to pharmacological chaperoning.


Synthesis and structure modification of ionic liquids to optimize their thermoelectric properties ArODES Scientifique

Pérez López Pilar, Uhl Stefanie, Laux Edith, Sanglard Pauline, Marti Roger, Keppner Herbert, Vanoli Ennio

Materials today: proceedings, 2018, 5, 1, pp. 10298-10305

Link to the publication

Summary:

Ionic Liquids (IL) are organic salts with melting temperature typically below 100 °C. The unique properties of ionic liquids such as their excellent chemical and thermal stabilities, their low vapor pressure, their important ionic conductivity makes them interesting compounds in material science and especially in thermoelectric generators (TEGs) for medical, pharma, or electronic applications. A big advantage of ILs is the endless number of cation/anion combinations, which allows synthesizing task-specific ionic liquids for TEG applications. This paper describes the synthesis, physical and electrochemical characterization of novel IL for application in thermoelectric generators (TEGs). We discuss the optimization of the chemical structure of IL regarding their thermoelectric properties via a structure-activity relationship approach. The best ionic liquids are the protic ones with a Seebeck coefficient of 570.24 µV/K for methylammonium trifluoroacetate and -1424.56 µV/K for ethylammonium formate.


Development of thermoelectric generator based on ionic liquids for high temperature applications ArODES Scientifique

Laux Edith, Uhl Stefanie, Gauthier Nicolas, Jeandupeux Laure, Keppner Herbert, Pérez López Pilar, Sanglard Pauline, Vanoli Ennio, Marti Roger

Materials Today: Proceedings, 2018, Vol. 5, No. 4, pp. 10195-10202

Link to the publication

Summary:

Current, Seebeck-coefficients (SE) and maximal power output (Pmax) of thermoelectric generators using Ionic Liquids (ILs) were measured to determine the optimal temperature window for their use as thermoelectric generators (TEGs) in the range between room temperature (RT) and 300°C. The IL was sandwiched in a thermoelectric cell between a heated and a cooled electrode, allowing temperature-dependent current, voltage, and power-output characterization. Dissolving redox-couples (e.g. I2/I-) enables charge transfer from the IL to the electrode. It was found, that protic ILs degraded irreversibly at 140°C. Aprotic ILs, however, in combination with LiI/I2 redox couples exhibit higher temperature stability being finally limited either by redox-couple-electrode reactions, by temperature-induced redox couple degradation or by reaching at the boiling point at about 280°C. ILs being solid at room temperature could successfully be activated, as soon as at least the hot electrode of the set-up was heated above the melting point (m.p.) of the IL. As a striking observation, the thermo-voltage (linked to the SE) changes the sign as soon as the cold electrode was kept below the m.p. when Ethylammonium tetrafluoroborate (EA BF4) was used. Another IL, Tetrabutylammonium tetrafluoroborate (TBA BF4) exhibited in the full temperature range negative SE as high as 7 mV/K.


One-pot synthesis of trifluoromethylated quinazolin-4(3H)-ones with trifluoroacetic acid as CF3 source ArODES Scientifique

Almeida Sofia, Marti Roger, Vanoli Ennio, Abele Stefan, Tortoioli Simone

The Journal of Organic Chemistry (JOC), 2018, 83, 9, pp. 5104-5113

Link to the publication

Summary:

A novel and convenient one-pot sequential cascade method for the preparation of 2-trifluoromethylquinazolin-4(3H)-ones is described. Trifluoroacetic acid (TFA) was employed as inexpensive and readily available CF3 source, which in the presence of T3P was condensed with a variety of anthranilic acids and amines to provide the products in up to 75% yield. The protocol was proved to be robust on 80 g scale, and the synthetic versatility of the prepared quinazolinon-4-ones was demonstrated by derivatization to further useful building blocks.




2017

Continuous Processes and Flow Chemistry at the Universities of Applied Sciences in Switzerland Scientifique

Christophe Allemann, Olivier Vorlet, Roger Marti

CHIMIA, 2017 , vol. 71, pp. 525-527

Link to the publication




2015

PAT at the Universities of Applied Sciences Scientifique

Michal Dabros, Olivier Vorlet, Roger Marti

CHIMIA, 2015 , vol. 69, no 7, pp. 482-484

Link to the publication




2013

CO2 Capture by Ionic Liquids – An Answer to Anthropogenic CO2 Emissions? Scientifique

Pauline Sanglard, Olivier Vorlet, Roger Marti, Olivier Naef

CHIMIA, 2013 , vol. 67, no 10, pp. 711-718

Link to the publication




2019

Swiss Chemical Society Conference

Roger Marti,

Fall Meeting 2019, 03.09.2019 - 03.09.2020, Bern

Summary:


Bioinspired Synthesis of Lignans

 


Achievements

Sans date

Student Projects

Marti Roger

Over the years I have been supervising various student projects, mainly Machelor and Master projects, as well as PhD's as co-supervisor. 
Most of these projects are in collaboration with industrial partners and some students were also working in the laboratories of the partner. I also have contacts with foreign universities, University of Bologna & University of Laval (Quebec), where students from my group are carrying out their project. 

Overview of projects 


Process Research & Scale-up for Support Drug Development

Marti Roger

We supported Dorphan SA, a small start-up active in the development of treatment of lysosomal storage diseases, in the preclinical development of their lead compound DO-1, an iminosugar derivative by working on the process development and scale-up of this highly complex molecule on up to 100 g’s of the API.

 

CTI Project “Intermediate scale manufacturing and in vivo therapeutic assessment of a promising drug candidate for the treatment of GM1-gangliosidosis” with Dorphan SA. 

Patent: 4-Epi-Isofagomine Enantiomer Derivatives for the Treatment of Lysosomal Storage Diseases - Stephane Demotz, Olivier Martin, Estelle Boivineau, Sophie Front, Julie Charollais-Thoenig, Roger Marti, Jean-Pascal Bourgeois, Sofia Almeida, WO2016174131 (A1).

Publication: 5a-C-Substituted 4-Epi-Isofagomine Derivatives as Pharmacological Chaperones for the    Treatment of Lysosomal Diseases Linked to b-Galactosidase Mutations: Improved Synthesis and Biological Investigations - Sophie Front, Sofia Almeida, Vincent Zoete, Julie Charollais-Thoenig, Estelle Gallienne, Cécile Marmy, Vincent Pilloud, Roger Marti, Tim Wood, Olivier R. Martin, Stéphane Demotz, Bioorg. Med. Chem. 2018, 26, 5462–5469 - 

Link to the achievement


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