Recherche

Milosevic Irena

Professeure HES assistante

Compétences principales

Functional Surfaces and Materials

Professeure HES assistante

Téléphone: +41 22 558 57 96

Bureau: A203a

Haute école du paysage, d'ingénierie et d'architecture de Genève
Rue de la Prairie 4, 1202 Genève, CH

Domaine
Technique et IT

Filière principale
Génie mécanique

Institut
inSTI - Institut des sciences et technologies industrielles

BSc HES-SO en Génie mécanique - Haute école du paysage, d'ingénierie et d'architecture de Genève

Science des matériaux

En cours

INTOX

Rôle: Collaborateur/trice

Financement: HES

Description du projet :

Nanotechnologies refer to technologies which exploit the unique properties of tiny particles of nanometre size (millionths of a millimetre), called nanoparticles (NPs). The NPs represent a fast-growing market. In fact, they are already being used in a variety of technologies and consumer products. Their attractive physicochemical properties for improving food taste and texture, increasing nutrient bioavailability, or their antimicrobial properties make them widely used in the food industry. For example, E151 and E171 are additives commonly used in food industry and refer respectively to SiO2 and TiO2 NPs. They are present in a lot of products and even in drugs. Many studies have shown that cellular or organ damage can occur in various places within the gastrointestinal tract, as well as after absorption of the NPs into the body. The role of the overproduction of reactive oxygen species was pointed out to be a key factor in NPs-induced toxicity. Nevertheless, no clear correlation nor study established the influence of the physicochemical properties of NPs and the Reactive oxygen species-induced cytotoxicity.

In this project, three kinds of NPs which are commonly used in food industry, will be produced with controlled properties : AgNPs, TiO2 NPs and SiO2 NPs. Moreover, detailed both chemical and physical characterisation of these NPs will be performed.

Afterwards, in order to assess their cytotoxic effect especially the one associated with ROS production in cells, in this project we will investigate the influence of key parameters related to NPs on cell viability. Such key parameters are for instance : the specific surface area, the presence of a surface coating (naked vs coated NPs) and the cristallinity (amorphous vs crystalline) of the NPs. In that purpose, a first screening will be done using uptake and cytotoxicity of the NPs in vitro on cell. The cytotoxicity associated with reactive oxygen species (ROS) generation will be highlighted in this study. Finally, Caenorhabditis elegans (C. elegans), an alternative in vivo model, will be used to test systemic response on an organism and the fate of ingested NPs.

The aim of this project is build a toolbox to predict NP-induced toxicity by discriminating the influence of different key parameters.

Equipe de recherche au sein de la HES-SO: Milosevic Irena

Durée du projet: 01.09.2020

Montant global du projet: 110'000 CHF

Statut: En cours

Innocem - Determination of scale-up parameters

Rôle: Collaborateur/trice

Requérant(e)s: Abhishek Kumar, Nanogence - Renens

Financement: GRS foundation

Description du projet :

The project is to determine the right operating conditions for the production machine to manufacture the tailored nanoparticle additives for the application in the construction sector.

The operating conditions are varied depending on the prior experience and calculation based on the lab production parameters. Different batches of the products are produced with variable parameters and material produced are analyzed with different analytical equipment and co-relation is developed between operating parameters and quality of the material.

Equipe de recherche au sein de la HES-SO: Milosevic Irena

Durée du projet: 01.08.2020

Montant global du projet: 220'000 CHF

Statut: En cours

Réalisations

Recherche

Milosevic Irena

Professeure HES assistante

Compétences principales

Nanoparticle synthesis

Nanotechnology

Materials characterization

Functional Surfaces and Materials

Material sciences

Nanocomposites & Nanofibers

Professeure HES assistante