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PEOPLE@HES-SO – Directory and Skills inventory

PEOPLE@HES-SO
Directory and Skills inventory

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Milosevic Irena

Milosevic Irena

Professeure HES associée

Main skills

Nanoparticle synthesis

Nanotechnology

Materials characterization

Functional Surfaces and Materials

Material sciences

Nanocomposites & Nanofibers

  • Contact

  • Teaching

  • Research

  • Publications

  • Conferences

Main contract

Professeure HES associée

Desktop: A203a

Haute école du paysage, d'ingénierie et d'architecture de Genève
Rue de la Prairie 4, 1202 Genève, CH
hepia
Faculty
Technique et IT
Main Degree Programme
Génie mécanique
MSc HES-SO en Engineering - HES-SO Master
BSc HES-SO en Génie mécanique - Haute école du paysage, d'ingénierie et d'architecture de Genève
  • Science des matériaux

Ongoing

Mechanical, chemical & structure properties of acoustic materials.
AGP

Role: Main Applicant

Financement: HES-SO Rectorat

Description du projet : The acoustic materials are highly porous and have specific mechanical and structure properties in order to produce sound effects. Some woods are known for centuries as the excellent acoustic materials and thus used for building of music instruments (as the violine). It was early recognized that properties of individual wood pieces of the same wood type can have very different acoustic performance. When going into smaller size pieces of an acoustic material, this effect is even more pronounced. For example: balsa wood is known as a great acoustic material for a long time, but the 100 different pieces of balsa wood having for example 4mm thickness, often have the different material properties (chemical, mechanical and structure) between them. The consequence is a different acoustic response of these pieces of the same material. But, this issue is not only happening with woods, as natural materials, but also with engineered materials, as acoustic foams made from various polymers.

Research team within HES-SO: Chambordon Marc , Milosevic Irena , Leduc Louise

Partenaires académiques: HEPIA inTECH

Durée du projet: 25.04.2025 - 31.12.2026

Montant global du projet: 7'500 CHF

Statut: Ongoing

INTOX

Role: Collaborator

Financement: HES

Description du projet :

 Nanotechnologies refer to technologies which exploit the unique properties of tiny particles of nanometre size (millionths of a millimetre), called nanoparticles (NPs). The NPs represent a fast-growing market. In fact, they are already being used in a variety of technologies and consumer products. Their attractive physicochemical properties for improving food taste and texture, increasing nutrient bioavailability, or their antimicrobial properties make them widely used in the food industry. For example, E151 and E171 are additives commonly used in food industry and refer respectively to SiO2 and TiO2 NPs. They are present in a lot of products and even in drugs. Many studies have shown that cellular or organ damage can occur in various places within the gastrointestinal tract, as well as after absorption of the NPs into the body. The role of the overproduction of reactive oxygen species was pointed out to be a key factor in NPs-induced toxicity. Nevertheless, no clear correlation nor study established the influence of the physicochemical properties of NPs and the Reactive oxygen species-induced cytotoxicity. 

In this project, three kinds of NPs which are commonly used in food industry, will be produced with controlled properties : AgNPs, TiO2 NPs and SiO2 NPs. Moreover, detailed both chemical and physical characterisation of these NPs will be performed. 

Afterwards, in order to assess their cytotoxic effect especially the one associated with ROS production in cells, in this project we will investigate the influence of key parameters related to NPs on cell viability. Such key parameters are for instance : the specific surface area, the presence of a surface coating (naked vs coated NPs) and the cristallinity (amorphous vs crystalline) of the NPs. In that purpose, a first screening will be done using uptake and cytotoxicity of the NPs in vitro on cell. The cytotoxicity associated with reactive oxygen species (ROS) generation will be highlighted in this study. Finally, Caenorhabditis elegans (C. elegans), an alternative in vivo model, will be used to test systemic response on an organism and the fate of ingested NPs. 

The aim of this project is build a toolbox to predict NP-induced toxicity by discriminating the influence of different key parameters. 

 

Research team within HES-SO: Milosevic Irena

Durée du projet: 01.09.2020

Montant global du projet: 110'000 CHF

Statut: Ongoing

Innocem - Determination of scale-up parameters

Role: Collaborator

Requérant(e)s: Abhishek Kumar, Nanogence - Renens

Financement: GRS foundation

Description du projet :

The project is to determine the right operating conditions for the production machine to manufacture the tailored nanoparticle additives for the application in the construction sector.

The operating conditions are varied depending on the prior experience and calculation based on the lab production parameters. Different batches of the products are produced with variable parameters and material produced are analyzed with different analytical equipment and co-relation is developed between operating parameters and quality of the material.

Research team within HES-SO: Milosevic Irena

Durée du projet: 01.08.2020

Montant global du projet: 220'000 CHF

Statut: Ongoing

Castable Lead-free Material for Antifriction Applications - CALEMAA

Role: Co-applicant

Financement: Innosuisse

Description du projet :

Kugler Bimetal (KB) is a company providing bearings for demanding applications in hydraulics, aeronautics and industrial machinery, featuring elevated requirements in terms of precision, stress, speed, and temperature. Today's production relies on bronze to which lead is added to ensure dry lubrication under extreme conditions. Because of both internal and customer environmental concerns, as well as an expected reinforcement of the REACH regulation, a Pb-free bronze solution has to be developed to win the market. 

In 2020, as a result of a CTI project, KB introduced successfully a first Pb-free solution specifically designed for laser cladding; however, laser cladding can be used only in limited bearing configurations. 80% of KB’s production relies rather on gravity casting, furnace brazing and induction brazing. These 3 technologies differentiate from laser cladding by a much lower alloy solidification rate, rendering the alloy that has been developed for laser cladding inadequate, because coarser resulting structures lead to insufficient properties in term of lubrification, hardness and embrittlement with this alloy. 

The aim of the present project is the design and production of a new Pb-free bearing bronze suited for the 3 aforementioned technologies. The project pools three academic institutions in addition to KB, and is to be led by the HEIG-VD. EPFL will be in charge of defining appropriate compositions building on a previous Innocheque study that identified Bi and Mn additions to tin bronze as a potential solution. HEIG-VD will conduct material fabrication and characterization while HEPIA will be in charge of tribological performance. 

Lack of a Pb-free solution would threaten KB’s existence and its 70 work places into question, while on the other hand bringing rapidly a solution to market will allow it to gain significant and growing market shares. An annual profit of 2 MCHF in 2028 and 8 MCHF in 2031 is expected from a successful completion of this project. 

Research team within HES-SO: Milosevic Irena , Müller Randoald

Statut: Ongoing

DISCOVERY AND PRE-CLINICAL DEVELOPMENT OF INHALABLE RSV PEPTIDES ANTIVIRALS

Role: Co-applicant

Financement: SNSF

Description du projet :

Respiratory Syncytial Virus (RSV) is a significant medical threat causing 33 million infections, 3.6 million hospitalizations, and 100’000 annual deaths each year worldwide. Furthermore, RSV infections accounts for 31% of global pneumonia cases, raising particular concern among young children with congenital heart diseases, chronic lung diseases and conditions affecting muscles and nerves. The costs associated with RSV infections, estimated at 4.82 billion euros in 2017, impose a considerable economic burden.
Although the recent launch of the antibody Nirsevimab will most likely help reduce RSV infections, and other vaccines appear to be close to approval, these biologics are all preventive treatment only, and there is no therapy available to treat infected patients. Since RSV infection begins and replicates in the respiratory tract (RT), targeting the RT at the replication sites appears to be an interesting strategy to block infection. In this perspective, patented anti-RSV peptides have been developed at the HES-SO Valais. These peptides block the fusion and the replication of the virus.

In this project, we wish to develop potent antiviral RSV peptide, with the aim to investigate them in tolerance, pharmacokinetics and feasibility studies. To enhance mucus permeation and/or deposit in the lungs, the use nanocarriers will be investigated. The overall objective will be to have selected an intranasal or pulmonary administration.
 

Research team within HES-SO: Milosevic Irena , Nyanguile Origène

Statut: Ongoing

Bactericidal nanoblades

Role: Collaborator

Requérant(e)s: Stane Pajk, University of Ljubljana, Slovénie

Financement: FNS

Description du projet :

Les biofilms offrent aux bactéries un bouclier mécanique protecteur et un milieu très favorable à leur développement et prolifération sur des surfaces. L’éradication des biofilms bactériens est devenue un enjeu primordial dans les domaines de la santé, de l'industrie agroalimentaire, l'approvisionnement en eau, les systèmes de ventilation et de traitement de l’air. Ainsi, il est primordial de trouver des solutions efficaces afin d’éradiquer les biofilms persistants. L'objectif principal de notre projet est de valider la faisabilité du concept des nanoblades bactéricides permettant l'élimination de biofilms de manière chimio-mécanique bimodale. Différents protocoles seront testés afin d’évaluer la performance de notre concept qui combine, en synergie, une action de destruction mécanique et une action bactéricide. La destruction mécanique se fera par la conversion de l'énergie magnétique en un mouvement de rotation de particules magnétiques anisotropes (facteur de forme) contrôlées à distance. La composante bactéricide sera fournie par la libération d'ions argent, générant un environnement antimicrobien à large spectre. Cette stratégie sera évaluée sur différentes combinaisons de biofilms bactériens et surfaces, y compris des bactéries très importantes pour le système de santé et l'industrie alimentaire. Le projet contient de nombreuses approches méthodologiques innovantes et ambitieuses nécessitant une expertise interdisciplinaire. La confirmation de l’approche chimio-mécanique peut avoir un impact énorme sur la santé publique car ce nouveau concept pourrait changer le paradigme de la lutte contre les biofilms dans l'industrie alimentaire et le système de santé.

Research team within HES-SO: Milosevic Irena

Partenaires académiques: Stane Pajk, University of Ljubljana, Slovénie

Montant global du projet: 481'335 CHF

Statut: Ongoing

Completed

Mechanical, chemical & structure properties of acoustic materials.
AGP

Role: Main Applicant

Financement: HES-SO Rectorat; Hidden Sound GmbH

Description du projet : The acoustic materials are highly porous and have specific mechanical and structure properties in order to produce sound effects. Some woods are known for centuries as the excellent acoustic materials and thus used for building of music instruments (as the violine). It was early recognized that properties of individual wood pieces of the same wood type can have very different acoustic performance. When going into smaller size pieces of an acoustic material, this effect is even more pronounced. For example: balsa wood is known as a great acoustic material for a long time, but the 100 different pieces of balsa wood having for example 4mm thickness, often have the different material properties (chemical, mechanical and structure) between them. The consequence is a different acoustic response of these pieces of the same material. But, this issue is not only happening with woods, as natural materials, but also with engineered materials, as acoustic foams made from various polymers.

Research team within HES-SO: Chambordon Marc , Boulandet Romain , Milosevic Irena , Leduc Louise , Van Der Ben Marco

Partenaires académiques: HEPIA inTECH

Durée du projet: 30.05.2024 - 01.03.2025

Montant global du projet: 67'000 CHF

Statut: Completed

2026

Magnetic field-driven strategies for biofilm disruption: from iron oxide nanoparticles to adaptive swarms of magnetic microrobots
Scientific paper

Milosevic Irena

ACS Nano, 2026

2022

Magnetic properties, phase evolution, hollow structure and biomedical application of hematite (a-Fe2O3) and QUAIPH
Scientific paper ArODES

Marin Tadic, Matjaz Panjan, Yoann Lalatone, Irena Milosevic, Biljana Vucetic Tadic, Jelena Lazovic

Advanced Powder Technology,  2022, vol. 33, no. 12, article no. 103847

Link to the publication

Summary:

We investigate synthesis, phase evolution, hollow and porous structure and magnetic properties of quasi-amorphous intermediate phase (QUAIPH) and hematite (α-Fe2O3) nanostructure synthesized by annealing of akaganeite (β-FeOOH) nanorods. It is found that the annealing temperature determines the phase composition of the products, the crystal structure/size dictates the magnetic properties whereas the final nanorod morphology is determined by the starting material. Annealing of β-FeOOH at ∼300 °C resulted in the formation of hollow QUAIPH nanorods. The synthesized material shows low-cytotoxicity, superparamagnetism and good transverse relaxivity, which is rarely reported for QUAIPH. The QUAIPH nanorods started to transform to porous hematite nanostructures at ∼350 °C and phase transformation was completed at 600 °C. During the annealing, the crystal structure changed from monoclinic (akaganeite) to quasi-amorphous and rhombohedral (hematite). Unusually, the crystallite size first decreased (akaganeite → QUAIPH) and then increased (QUAIPH → hematite) during annealing whereas the nanorods retained particle shape. The magnetic properties of the samples changed from antiferromagnetic (akaganeite) to superparamagnetic with blocking temperature TB = 84 K (QUAIPH) and finally to weak-ferromagnetic with the Morin transition at TM = 244 K and high coercivity HC = 1652 Oe (hematite). The low-cytotoxicity and MRI relaxivity (r2 = 5.80 mM−1 s−1 (akaganeite), r2 = 4.31 mM−1 s−1 (QUAIPH) and r2 = 5.17 mM−1 s−1 (hematite)) reveal potential for biomedical applications.

Poly(methyl methacrylate) with oleic acid as an efficient candida albicans biofilm repellent
Scientific paper ArODES

Milica Petrovic, Marina Randjelovic, Marko Igic, Milica Randjelovic, Valentina Arsic Arsenijevic, Marijiana Mionic Ebersold, Suzana Otasevic, Irena Milosevic

Materials,  2022, vol. 15, no. 11, article no. 3750

Link to the publication

Summary:

Poly(methyl methacrylate) (PMMA), widely used in dentistry, is unfortunately a suitable substrate for Candida (C.) albicans colonization and biofilm formation. The key step for biofilm formation is C. albicans ability to transit from yeast to hypha (filamentation). Since oleic acid (OA), a natural compound, prevents filamentation, we modified PMMA with OA aiming the antifungal PMMA_OA materials. Physico-chemical properties of the novel PMMA_OA composites obtained by incorporation of 3%, 6%, 9%, and 12% OA into PMMA were characterized by Fourier-transform infrared spectroscopy and water contact angle measurement. To test antifungal activity, PMMA_OA composites were incubated with C. albicans and the metabolic activity of both biofilm and planktonic cells was measured with a XTT test, 0 and 6 days after composites preparation. The effect of OA on C. albicans morphology was observed after 24 h and 48 h incubation in agar loaded with 0.0125% and 0.4% OA. The results show that increase of OA significantly decreased water contact angle. Metabolic activity of both biofilm and planktonic cells were significantly decreased in the both time points. Therefore, modification of PMMA with OA is a promising strategy to reduce C. albicans biofilm formation on denture.

2025

Automated image-based detection of surface porosity defects in metals
Conference ArODES

Antoine Ottiger, Hannes Freisse, Irena Milosevic, Jérôme Extermann, Enrico Pomarico

AI days HES-SO '25

Link to the conference

Summary:

Porosity defects in metals can severely impact material properties and performance. Standard porosity detection techniques, such as dye penetrating testing, are time-consuming and often lack precision. In this study, we report on a deep-learning multi-class segmentation model developed to automatically identify porosities on laser-deposited bronze surfaces over steel, after lathe machining. Using samples with four distinct roughness levels, we constructed a dataset of 216 images (512 x 512 pixels each), labeled across three classes: background, uncovered porosity, and bronze-covered porosity. The model achieves F1-scores of 90% and 75% for the last classes, demonstrating its effectiveness in distinguishing porosity types. This model enables quantitative analysis of porosity geometry, revealing that, regardless of surface roughness, the average major and minor axes are approximately 0.2 mm, with a mean shape factor of 1.4 and an average area of 0.03 mm2. Notably, as roughness decreases, covered porosity levels rise non-linearly, likely due to material spreading during low-feed-rate facing operations.

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