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PEOPLE@HES-SO – Annuaire et Répertoire des compétences

PEOPLE@HES-SO
Annuaire et Répertoire des compétences

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Diep Kim-Long

Diep Kim-Long

Collaborateur scientifique HES

Compétences principales

Organic Chemistry

Organic Synthesis

Chemical biology

DNA Chemistry

Photochemistry

Process chemistry and scale-up

Chemical Production

  • Contact

  • Publications

Contrat principal

Collaborateur scientifique HES

Bureau: B00.20

Haute école d'ingénierie et d'architecture de Fribourg
Boulevard de Pérolles 80, 1700 Fribourg, CH
HEIA-FR
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2025

A scalable dynamic cascade flow reactor for challenging continuous heterogeneous processes
Article scientifique ArODES

Kim-Long Diep, Emilie Bucs, Marlies Moser, Finn L. Steinemann, Alain G. Georg, Flavien L. Morel, Michal Dabros, Roger Marti

CHIMIA,  2025, 79, 6, 433-440

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Résumé:

Continuous processes (often referred to as flow chemistry) offers multiple advantages over batch processes and are of particular interest for industrial applications as they provide a more direct path towards process intensification, increased safety and efficiency. However, some chemical processes are still challenging to run in a continuous fashion, such as reactions producing fouling, using stoichiometric amounts of solids, or requiring long residence times. For those kinds of reactions, batch approaches are usually preferred even though some processes would still benefit from the advantages inherent to flow. We herein report our testing and development of a scalable continuous flow reactor equipped with active mixing that was designed to handle those challenging continuous processes, such as the continuous formation of a Grignard reagent from a magnesium powder slurry.

2022

Forchlorfenuron and Novel Analogs Cause Cytotoxic Effects in Untreated and Cisplatin-Resistant Malignant Mesothelioma-Derived Cells
Article scientifique

Thomas Henzi, Diep Kim-Long, Anne Oberson, Valerie Salicio, Christian G. Bochet, Beat Schwaller

International Journal of Molecular Sciences, 2022 , vol.  23, no  7, pp.  3963-3699

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2021

Self-immolative phenylcarbonates for nucleic acid templated reactions
Thèse de doctorat

Diep Kim-Long

2021,  Fribourg (CH) : Université de Fribourg.  202  p.

Bochet Christian G.

2020

A Simple Reaction for DNA Sensing and Chemical Delivery
Article scientifique

Elia Janett, Diep Kim-Long, Katharina M. Fromm, Christian G. Bochet

ACS Sensors, 2020 , vol.  5, no  8, pp.  2338-2343

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2019

The phytohormone forchlorfenuron decreases viability and proliferation of malignant mesothelioma cells in vitro and in vivo
Article scientifique

Walter Blum, Thomas Henzi, László Pecze, Diep Kim-Long, Christian G. Bochet, Beat Schwaller

Oncotarget, 2019 , vol.  10, no  65, pp.  6944-6956

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