Description du projet :
Background: Motor learning is a crucial issue in the re-acquisition of complex upper limb motor skills after stroke. Recent studies have identified novel neurobiological surrogate marker (i.e., functional connectivity (FC) between the parietal and primary motor cortex) associated with motor performance. This enables to refine our current model of motor learning wherein specific cortical connectivity is a key factor for motor acquisition. Furthermore, recent evidence suggests that new repetitive transcranial magnetic stimulation (rTMS) approach such as “intermittent theta-burst stimulation” (iTBS), can influence this key factor. However, up to now, no iTBS studies have target this surrogate marker. In contrast with conventional rTMS paradigm that focus only on monofocal stimulation, innovative approach may consist of multifocal iTBS able to increase specific brain network interactions rather one brain region activity. However, the effects of multifocal iTBS applied over the parietal cortex (PC) and primary motor (M1) areas are unknown. Hence, we want to develop a new iTBS setup able to induce specific brain connectivity in stroke individuals that are likely to benefit. This has the potential to obtain critical information in order to improve treatment of motor re-learning in patients with neurological diseases.
Objective: This project proposes to investigate a new multifocal iTBS paradigm resulting from recent advances in the understanding of motor skill acquisition. In this work, we will test the hypothesis that multiple sessions of multifocal iTBS applied over critical brain regions and combined with the utilization of assistive interactive interface, specifically the REAtouch®, will lead to improved motor acquisition and long-term retention of learned skills.
Methods: This project will include a non-invasive brain stimulation paradigm, wherein the multifocal iTBS settings will be tested on stroke subjects. This setting will be used in a randomized-control parallel groups trial comparing multifocal iTBS over the PC and M1 area to sham stimulation. Learning performance will be measured during each training session as well as one day and one week after the last training session to test for short- and long-term retention.
Significance: The original empirical data collected, and the overall results of this project will advance current knowledge on the impact and potential benefits of iTBS strategy in motor learning domain. Results may shed new light for improving learning outcomes and form the basis for the translation of research into clinical practice and improve our current recommendations.
Equipe de recherche au sein de la HES-SO:
Nicolo Pierre
, Chéchin Adrien
Partenaires académiques: PD Dr Nicolas Nicastro, Médecin adjoint agrégé, Spéc. FMH en Neurologie, Hôpitaux Universitaire de Genève, Suisse
Durée du projet:
01.09.2024 - 01.02.2026
Statut: En cours
SWITCH edu-ID
Administration
