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PEOPLE@HES-SO - Verzeichnis der Mitarbeitenden und Kompetenzen
PEOPLE@HES-SO - Verzeichnis der Mitarbeitenden und Kompetenzen

PEOPLE@HES-SO
Verzeichnis der Mitarbeitenden und Kompetenzen

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Moreillon Fabien

Moreillon Fabien

Adjoint-e scientifique ou artistique HES

Hauptkompetenzen

Microtechnique

Bioingénierie

Electronique

Mécanique

Systèmes embarqués

Microcontrollers

Gestion de projets

  • Kontakt

  • Publikationen

  • Konferenzen

Hauptvertrag

Adjoint-e scientifique ou artistique HES

Büro: Campus BioTech - B3-04 230.118

Haute école du paysage, d'ingénierie et d'architecture de Genève
Rue de la Prairie 4, 1202 Genève, CH
hepia
Bereich
Technique et IT
Hauptstudiengang
Microtechniques
Es müssen keine Daten für diesen Abschnitt angezeigt werden.

2025

Spontaneous recovery from rocuronium measured by mechanomyography during 100- or 200-Hz tetanic stimulations compared to normalized train-of-four with acceleromyography
Wissenschaftlicher Artikel ArODES

Philippe E. Dubois, Fabien Moreillon, Benoit Bihin, Clotilde De Dorlodot, Sabrina Meyer, Adrien Maseri, Philippe A. Passeraub

Journal of Clinical Monitoring and Computing,  2025

Link zur Publikation

Zusammenfassung:

Neuromuscular block recovery was evaluated using high-frequency tetanic ulnar nerve simulations compared to normalized train-of-four (NTOF) in anesthetized patients. Under intravenous general anesthesia, we compared rocuronium-induced neuromuscular recovery using 5 s 100- and 200-Hz tetanic stimulations via isometric mechanomyography to acceleromyographic NTOF in 20 consenting patients. The primary outcome was the comparison by Student’s t-tests of 100- and 200-Hz tetanic fade ratios (residual force at the end of the contraction / maximal force reached during the 5 s) before rocuronium administration and at different recovery levels. The secondary outcome was the quantification of any significant fade occurring with 100- and 200-Hz stimulations after reaching the acceleromyographic NTOF ratio of 0.9 during subsequent stages of spontaneous recovery until their fade ratios exceeded 0.9. During early (TOF count ≥ 1) and intermediate (NTOF ratio ≥ 0.5) stages of recovery, both 100- and 200-Hz tetanic fade ratios were similarly low. However, during late recovery when NTOF ratio ≥ 0.9, 200-Hz stimulation induced a significantly deeper muscular fade than 100-Hz (tetanic fade ratio 0.20 ± 0.23 vs. 0.64 ± 0.29, P < 0.001). The delays between the recovery of NTOF ratio 0.9 and 100- or 200-Hz tetanic fade ratio 0.9 were 7.7 ± 7.1 and 43.6 ± 14.6 min, respectively. In anesthetized humans, mechanomyographic 200-Hz tetanic stimulation detects lighter levels of residual paralysis than NTOF and 100-Hz tetanic stimulation during a valuable additional period. Registered in the ClinicalTrials.gov Registry NCT05474638 on July 15th 2022.

2021

100?Hz-5?s tetanic stimulation to illustrate the presence of “residual paralysis” co-existing with accelerometric 0.90 train-of-four ratio—A proof-of-concept study
Wissenschaftlicher Artikel ArODES

Bertrand Debaene, Denis Frasca, Fabien Moreillon, Alain A. D'Hollander

Anaesthesia Critical Care Pain Medicine,  2021, vol. 40, no. 4, article no. 100903

Link zur Publikation

Zusammenfassung:

An acceleromyographic train-of-four (TOF) ratio of 0.90 at extubation does not prevent postoperative pulmonary complications in surgical patients receiving non-depolarising muscle relaxants. This recent observation suggests that a more selective neuromuscular transmission monitoring parameter is mandatory to detect more precisely any remaining residual paralysis. The aim of our proof-of-concept study was to evaluate, in patients receiving rocuronium, the degree of 100-Hz, 5-s tetanic fade present when the acceleromyographic TOF ratio has recovered to 0.90. Twenty adult patients scheduled for surgery under general anaesthesia were included. Before anaesthesia induction, a TOF-Watch SX™ and a VISUAL-ITF© (a prototype monitor for recording isometric force) were positioned on both hands. After induction but before rocuronium injection, a 100-Hz, 5-s tetanus (TET0) was delivered to both ulnar nerves. Thereafter, TOF stimulations every 15 s were delivered to both arms until a TOF ratio > 0.90 was recorded; then, a 100-Hz, 5-s tetanus (TET1) was recorded on the VISUAL-ITF© monitor. The values of the tetanic parameters (force) recorded at TET0 and TET1 were compared using a Wilcoxon rank sum test. Compared to TET0, tetanic parameters of TET1 were significantly lower (median [range]): maximal force 36.4 [19.2−82.6] vs. 25.5 [5.0−42.4] Newton (p <  0.005); residual force 36.2 [18.2−82.0] vs. 5.5 [0.20–38.3] Newton (p < 0.0001) and residual force/maximal force ratio 0.98 [0.89−0.99] vs. 0.17 [0.03−0.90] (p <  0.0001). Our results confirm that even when the acceleromyographic TOF ratios have recovered to above 0.90, the contralateral 100-Hz, 5-s tetanic stimulus may show tetanic fade characteristic of residual neuromuscular block, and may help improve the safety of tracheal extubation.

The interest of 100 versus 200 Hz tetanic stimulations to quantify low levels of residual neuromuscular blockade with mechanomyography: a pilot study
Wissenschaftlicher Artikel ArODES

Philippe E. Dubois, John Mitchell, Maxime Regnier, Philippe A. Passeraub, Fabien Moreillon

Journal of Clinical Monitoring and Computing,  2021

Link zur Publikation

Zusammenfassung:

A more sensitive method than the train-of-four ratio seems required to detect low levels of residual neuromuscular blockade before tracheal extubation. The goal of the study was to determine the potential benefit of 5 s of 100 versus 200 Hz tetanic stimulation to quantify the residual block with mechanomyography in anesthetised patients. Twenty informed and consenting 18- to 80-year-old patients undergoing nose surgery were included. On the left hand, neuromuscular transmission was continuously monitored by acceleromyography. On the right side, a new mecanomyographic device (Isometric Thumb Force©) recorded the force of thumb adduction (N) developed during 5 s of 100- and 200 Hz tetanic stimulations of the ulnar nerve at three consecutive times: baseline before inducing the neuromuscular blockade, at the time of contralateral train-of-four ratio 0.9 recovery, and 3 min after additional sugammadex reversal. Tetanic Fade Ratios (TFR = F residual/F max) were compared between 100 and 200 Hz stimulations using Student’s t test. At the time of TOF ratio 0.9 recovery, both 100 and 200 Hz TFR were significantly decreased compared to baseline (0.61 and 0.16 on average, respectively, p < 0.0001). The 200 Hz TFR was significantly lower than the 100 Hz TFR (p < 0.0001). There were no differences between baseline and post-reversal TFR. The 200 Hz TFR has the potential to better describe low levels of residual neuromuscular blockade than the TOF ratio and 100 Hz TFR and would benefit from further investigations. Retrospectively registered in the Australian and New Zealand Clinical Trials Registry ACTRN12619000273189.

2020

Fabrication and characterization of a flexible fluxgate sensor with pad-printed solenoid coils
Wissenschaftlicher Artikel ArODES

Spyridon Schoinas, Adyl-Michaël El Guamra, Fabien Moreillon, Philippe Passeraub

Sensors,  2020, vol. 20, no. 8, article no. 2275

Link zur Publikation

Zusammenfassung:

This paper presents the fabrication and characterization of a flexible, flat, miniaturized fluxgate sensor with a thin amorphous rectangular magnetic core fabricated by the pad/printing technique. Both the design and the various printing steps of the sensor are presented. The fluxgate sensor comprises of solenoid coils, and to the best of our knowledge, is the first to be printed with a conventional micro-printing technique. The magnetic core is a non-printed component, placed between the printed layers. The sensor’s linear measuring range is ±40 µT with 2% full-scale linearity error, at 100 kHz excitation frequency. The highest measured sensitivity reaches 14,620 V/T at 200 kHz, while the noise of the sensor was found to be 10 nT/ √Hz at 1 Hz.

2019

A versatile robotic platform for the design of natural, three-dimensional reaching and grasping tasks in monkeys
Wissenschaftlicher Artikel ArODES

B. Barra, Marion Badi, Matthew G. Perich, Sara Conti, Seyed Sina Mirrazavi Salehian, Fabien Moreillon, Andrew Bogaard, Sophie Wurth, Mélanie Kaeser, Philippe Passeraub, Tomislav Milekovic, Aude Billard, Silvestro Micera, Marco Capogrosso

Journal of Neural Engineering,  2020, vol. 17, no. 1, article no. 016004

Link zur Publikation

Zusammenfassung:

Objective. Translational studies on motor control and neurological disorders require detailed monitoring of sensorimotor components of natural limb movements in relevant animal models. However, available experimental tools do not provide a sufficiently rich repertoire of behavioral signals. Here, we developed a robotic platform that enables the monitoring of kinematics, interaction forces, and neurophysiological signals during user-defined upper limb tasks for monkeys. Approach. We configured the platform to position instrumented objects in a three-dimensional workspace and provide an interactive dynamic force-field. Main results. We show the relevance of our platform for fundamental and translational studies with three example applications. First, we study the kinematics of natural grasp in response to variable interaction forces. We then show simultaneous and independent encoding of kinematic and forces in single unit intra-cortical recordings from sensorimotor cortical areas. Lastly, we demonstrate the relevance of our platform to develop clinically relevant brain computer interfaces in a kinematically unconstrained motor task. Significance. Our versatile control structure does not depend on the specific robotic arm used and allows for the design and implementation of a variety of tasks that can support both fundamental and translational studies of motor control.

2017

A flexible pad-printed fluxgate sensor
Wissenschaftlicher Artikel

Schoinas Spyridon, Adyl-Michaël El Guamra, Moreillon Fabien, Passeraub Philippe,

Proceedings of Eurosensors 2017, 3-6 September 2017, Paris, France, 2017 , vol.  2017, vol. 1, no. 615

Link zur Publikation

Zusammenfassung:

A flexible flat micro-Fluxgate sensor with amorphous rectangular core, fabricated using a simple printing technique is presented. All materials were selected to facilitate the fabrication process and to achieve optimal sensor performance. The device’s response to an externally applied magnetic field has been studied. The linear measuring range of the sensor is approximately ±40 μT with a linearity error of <2% FS at 100 kHz excitation frequency, allowing the measurement of the terrestrial magnetic field. Experimental results demonstrate that the behaviour of the fabricated device corresponds to the behaviour of a Fluxgate sensor with high sensitivity.

2015

Simulation and experimental characterizations of a thin touch mode capacitive pressure sensor
Wissenschaftlicher Artikel

Adyl-Michaël El Guamra, Damien Bühlmann, Moreillon Fabien, Luc Vansteenkiste, Philippe Büchler, Andreas Stahel, Passeraub Philippe

Proceedings of COMSOL Conference 2015, 14-16 October 2015, Grenoble, France, 2015

Link zur Publikation

Zusammenfassung:

This study describes a thin and lowcost capacitive pressure sensor and a model elaborated by the finite element method (FEM) in touch mode for monitoring fluid pressure from 0 to 40kPa in a perfusion chamber with Luer fittings for medical applications. The touch mode is expected to provide good linearity, large measuring range and large overload protection [1]. The choice of a thin polymer membrane as sensitive element with a printed circular electrode reduces drastically the thickness and fabrication costs in comparison to standard microfabrication processes. A set of assumptions were successfully applied to reduce the computation time of the model which was validated by comparison with experiments. The principle, characteristics and a methodology of FEM model for a specific touch mode capacitive-type pressure sensor are illustrated in the report.

2018

Advanced Lightsheet Imaging Center (ALICE)
Konferenz

S Pagès, L Batti, F Voigt, G Reymond, C Brana, A Tissot, A Holtmaat, C Luscher, G Courtine, F Helmchen, Moreillon Fabien, Passeraub Philippe, J Donoghue

The 11th FENS Forum of Neuroscience, 07.07.2018 - 11.04.2018, Berlin, Germany

DIAGNOTOX
Konferenz
«Réalité augmentée» pour le monitorage et le test de toxicité in vitro (Poster et stand)

Passeraub Philippe, Moreillon Fabien

Journée HES-SO Diagnostic Biochips en collaboration avec la Fondation Inartis et la Health Valley, 18.05.2018 - 18.05.2018, Etoy, Switzerland

Link zur Konferenz

Visual-ITF
Konferenz
Making anesthesia safer Precisely informing the anesthetist about curare effects and residues

Passeraub Philippe, Moreillon Fabien, Alain D'Hollander

Geneva Health Forum, 10.04.2018 - 12.04.2018, Geneva, Switzerland

Médecine préventive
Konferenz
Comment sécuriser et améliorer les gestes médicaux grâce à Visual ITF, nouvel instrument dédié à l’anesthésie ?

Alain d'Hollander, Passeraub Philippe, Moreillon Fabien

MEDI’NOV Connection 2018, 21.03.2018 - 22.03.2018, Grenoble, France

2017

A flexible pad-printed fluxgate sensor
Konferenz ArODES

Spyridon Schoinas, Adyl-Michaël El Guamra, Fabien Moreillon, Philippe Passeraub

Proceedings of Eurosensors 2017, 3-6 September 2017, Paris, France

Link zur Konferenz

Zusammenfassung:

A flexible flat micro-Fluxgate sensor with amorphous rectangular core, fabricated using a simple printing technique is presented. All materials were selected to facilitate the fabrication process and to achieve optimal sensor performance. The device’s response to an externally applied magnetic field has been studied. The linear measuring range of the sensor is approximately ±40 μT with a linearity error of <2% FS at 100 kHz excitation frequency, allowing the measurement of the terrestrial magnetic field. Experimental results demonstrate that the behaviour of the fabricated device corresponds to the behaviour of a Fluxgate sensor with high sensitivity.

2015

Simulation and experimental characterizations of a thin touch mode capacitive pressure sensor
Konferenz ArODES

Adyl Michaël El Guamra, Damien Bühlmann, Fabien Moreillon, Luc Vansteenkiste, Philippe Büchler, Andreas Stahel, Philippe Passeraub

Proceedings of COMSOL Conference 2015, 14-16 October 2015, Grenoble, France

Link zur Konferenz

Zusammenfassung:

This study describes a thin and lowcost capacitive pressure sensor and a model elaborated by the finite element method (FEM) in touch mode for monitoring fluid pressure from 0 to 40kPa in a perfusion chamber with Luer fittings for medical applications. The touch mode is expected to provide good linearity, large measuring range and large overload protection [1]. The choice of a thin polymer membrane as sensitive element with a printed circular electrode reduces drastically the thickness and fabrication costs in comparison to standard microfabrication processes. A set of assumptions were successfully applied to reduce the computation time of the model which was validated by comparison with experiments. The principle, characteristics and a methodology of FEM model for a specific touch mode capacitive-type pressure sensor are illustrated in the report.

2007

Development of a low-noise 64-channel measurement system for low frequency bioelectrial signals
Konferenz ArODES

Fabien Moreillon, Philippe A. Passeraub

Proceedings of Swiss Society of Biomedical Engineering (SSBE) Annual Meeting, 13-14 September 2007, Neuchâtel, Switzerland

Link zur Konferenz

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