This study examined whether adolescents' perceptions and reactions to parental regulation were predicted by parents' communication style and by adolescents' self-determination. Adolescents (N = 294; Mage = 14.3) reported their self-determination, and then read a hypothetical scenario of parental regulation of their academic behavior, whereby parents' communication style was either autonomy-supportive or psychologically controlling. Following the scenario, adolescents reported their perceptions of the situation (i.e., autonomy satisfaction, autonomy frustration, legitimacy) and their anticipated responses (i.e., oppositional defiance, negotiation). In response to psychological control, adolescents reported less autonomy satisfaction, more autonomy frustration, less legitimacy, and more defiance. Further, adolescents higher in self-determination reported less autonomy frustration, more legitimacy, less defiance, and more negotiation. Finally, self-determination moderated two effects of communication style: adolescents low on self-determination reported less legitimacy and more defiance in response to the psychologically controlling (vs. autonomy-supportive) situation. For adolescents high on self-determination, these between-vignette differences were not significant.