Introduction : After a kidney transplant, patients continue to live with symptoms, although little studied so far in French-speaking Switzerland. Method : A cross-sectional correlational description of work was used to explore the relationship between symptoms and quality of life (QOL) of kidney transplant patients followed at the Organ Transplant Center of the Lausanne University Hospital. Results : On average, the most prevalent symptoms among participants (N = 76) were lack of energy, dry skin, difficulty falling asleep, irritability, nervousness. Eighty per cent of participants rated their QOL as good or very good. All correlations between symptoms and QOL level of participants were significant and negative. Regressions revealed a persistent link between symptoms and the social dimension of participants’ QOL. Conclusion : Despite transplantation, patients experience many symptoms, which can affect their QOL.