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PEOPLE@HES-SO - Verzeichnis der Mitarbeitenden und Kompetenzen
PEOPLE@HES-SO - Verzeichnis der Mitarbeitenden und Kompetenzen

PEOPLE@HES-SO
Verzeichnis der Mitarbeitenden und Kompetenzen

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Jungo Rhême Carmen

Jungo Rhême Carmen

Professeure HES ordinaire/Responsable de centre de compétences

Hauptkompetenzen

Biotechnology

Process scale-up & -down

Mammalian cell culture

Microbiologie et bactériologie

Recombinant peptides and proteins

Good Manufacturing Practices (GMP)

Project Management

  • Kontakt

  • Lehre

  • Publikationen

  • Konferenzen

  • Portfolio

Hauptvertrag

Professeure HES ordinaire/Responsable de centre de compétences

Haute école d'ingénierie et d'architecture de Fribourg
Boulevard de Pérolles 80, 1700 Fribourg, CH
HEIA-FR
BA HES-SO en Architecture - Haute école d'ingénierie et d'architecture de Fribourg
  • Génie des procédés

2014

Yeast Suspension culture.
Wissenschaftlicher Artikel
Industrial Scale Suspension Culture of Living Cells.

Jungo Rhême Carmen, D. Mattanovich, J. Wenger, Dabros Michal, M. Maurer

Book in Wiley VCH Verlag GmBh & Co. KGaA, 2014 , pp.  94-129

2010

Design and Optimization of a Large Scale Biopharmaceutical Facility Using Process Simulation and Scheduling Tools.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, A. Toumi, V. Paravasileiou, D. Petrides, C. Jürgens, B. Maier

ISPE, 2010 , vol.  2, no  30

2008

An Emerging Star for Therapeutic and Catalytic Protein Production.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, H.P. Meyer, J. Brass, J. Klein, J. Wenger, R Mommers

BioProcess International, 2008

2007

Mixed feeds of glycerol and methanol can improve the performance of Pichia pastoris cultures
Wissenschaftlicher Artikel
A quantitative study based on concentration gradients in transient continuous cultures.

Jungo Rhême Carmen, I.W. Marison, U. von Stockar

Journal of Biotechnology, 2007 , vol.  4, no  128, pp.  824-837

Regulation of alcohol oxidase of a recombinant Pichia pastoris Mut+ strain in transient continuous cultures.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, I. W. Marison, U. von Stockar

Journal of Biotechnology, 2007 , vol.  3, no  130, pp.  236-246

A quantitative analysis of the benefits of mixed feeds of sorbitol and methanol for the production of recombinant avidin with Pichia pastoris.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, J. Schenk, M. Pasquier, I.W. Marison, U. von Stockar

Journal of Biotechnology, 2007 , vol.  1, no  131, pp.  57-66

Influence of specific growth rate on specific productivity and glycosylation of a recombinant avidin produced by a Pichia pastoris Mut+ strain.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, J. Schenk, K. Balazs, J. Urfer, C. Wegmann, A. Zocchi, I.W. Marison, U. von Sockar

Biotechnology and Bioengineering, 2007 , vol.  2, no  99, pp.  368-377

Optimisation of culture conditions with respect to biotin requirement for the production of recombinant avidin in Pichia pastoris.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, J. Urfer, A Zocchi, I.W. Marison, U. von Stockar

Journal of Biotechnology, 2007 , vol.  4, no  127, pp.  703-715

2006

Quantitative characterization of the regulation of the synthesis of alcohol oxidase and of the expression of recombinant avidin in a Pichia pastoris Mut+ strain.
Wissenschaftlicher Artikel

Jungo Rhême Carmen, C. Rérat, I.W. Marison, U. Stockar

Enzyme and Microbial Technology, 2006 , vol.  39, no  4, pp.  936-944

2008

Alternative cultivation strategies with Pichia pastoris for the production of therapeutic recombinant proteins.
Konferenz

Jungo Rhême Carmen

BioTech 2008 and 4th Swiss-Czech Symposium, 22.05.2008 - 23.05.2008, Wädenswil (CH)

Link zur Konferenz

2006

Rapid and rational strain characterization with transient continuous cultures monitored by calorimetry
Konferenz

Jungo Rhême Carmen

6th European Symposium on Biochemical Engineering Science, 27.08.2006 - 30.08.2006, Salzbourg, Austria

2005

Understanding regulation of recombinant protein expression in Pichia pastoris.
Konferenz

Jungo Rhême Carmen

BioTech 2005 and 3rd Swiss-Czech Symposium, 17.05.2005 - 19.05.2005, Wädenswil (CH)

Link zur Konferenz

Errungenschaften

2023

Research projects in biopharmaceutical industry

 2023 ; Upstream and downstream process development and implementation

Collaborateurs: Jungo Rhême Carmen

I led research projects in industry, for example at Lonza Biopharmaceutical R&D Upstream process development group where I developed new processes for the expression and production of therapeutic proteins by fermentation with bacteria (Escherichia coli, Bacillus subtilis, Pseudonomas strains) and yeasts (Pichia pastoris) and supervised up to 5 lab technicians. More precisely, I was responsible for the development and optimization of new microbial processes at lab scale as well as the scale-up and technology transfer to the manufacturing scale. Part of my research activities were published and presented in international conferences. At CSL Behring AG, I managed 3 teams of senior scientists and technicians, in total 18 people, for the development and optimization of the purification processes for the manufacturing of plasma-derived biotherapeutic proteins. The main responsibility was the delivery of a robust and well-characterized Immunoglobulin manufacturing process achieving higher IgG yields for the products Privigen® and
Hizentra®, which are among the most important products in the CSL Behring portfolio. This work was confidential and was not publised.

2020

Project management for biopharmaceutical industry

 2020 ; Project execution and implementation

Collaborateurs: Jungo Rhême Carmen

At CSL Behring AG, I was first responsible the first two years for the initiation, planning, execution and monitoring of global and local R&D projects predominantly around life cycle management of drug products, ensuring detailed, realistic and accurate planning in regard to timelines and resources.
I then moved to the Strategic Projet Portfolio and Operational Excellence Department and I was responsible for the execution of „Genesis II“ project, which consisted in the upgrade of a manufacturing bulk facility, the adaptation of an existing filing line, the implementation of a new lyophilisation facility,
the upgrade of visual inspection and the implementation of packaging & labelling for the launch of the new commercial product called “CSL112”, which is an active Apolipoprotein A-I, purified from human plasma. In this project I assembled and managed a cross-functional project team of more than 30 team
members for a total investment of 90 mio USD.

2008

Expression of recombinant proteins with Pichia pastoris

 2008 ; Upstream process development, technology transfer and scale up

Collaborateurs: Jungo Rhême Carmen

During my PhD Thesis at EPFL, I developed new fed-batch cultivation strategies with mutliple nutrient limitations for the improved high cell density production of recombinant therapeutic proteins with yeasts (Pichia pastoris). I published my work in four publications as first author and I presented my
achievements at two international conferences. The outcome was implemented for example at Lonza at large scale for the optimal expression of recombinant proteins with the yeast Pichia pastoris.

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